abstract：OBJECTIVE:To clarify the relationship between the angiotensin I-converting enzyme (ACE) gene polymorphism and diabetic micro- and macroangiopathy in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:We examined 267 NIDDM patients with various stages of diabetic retinopathy, 61 ...

journal_title：Diabetes care

authors： Fujisawa T,Ikegami H,Shen GQ,Yamato E,Takekawa K,Nakagawa Y,Hamada Y,Ueda H,Rakugi H,Higaki J

更新日期：1995-07-01 00:00:00

abstract：OBJECTIVE:Strict glycemic control in people with insulin-dependent diabetes mellitus (IDDM) reduces the risk of microvascular complications, but improvements in control are also associated with weight gain. Fears about the mortality risks of obesity may limit the acceptability of tight control. Therefore, we examined m...

journal_title：Diabetes care

authors： Chaturvedi N,Stevens LK,Fuller JH

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:To investigate whether insulin resistance and microalbuminuria are associated in non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Insulin sensitivity was assessed using a hyperinsulinemic euglycemic clamp in 11 normoalbuminuric and 9 microalbuminuric NIDDM patients matched for sex...

journal_title：Diabetes care

authors： Nielsen S,Schmitz O,Orskov H,Mogensen CE

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of metabolic control in the progression of diabetic retinopathy during pregnancy. RESEARCH DESIGN AND METHODS:We conducted a prospective cohort study of 155 diabetic women in the Diabetes in Early Pregnancy Study followed from the periconceptional period to 1 month postpartum. Fundus pho...

journal_title：Diabetes care

authors： Chew EY,Mills JL,Metzger BE,Remaley NA,Jovanovic-Peterson L,Knopp RH,Conley M,Rand L,Simpson JL,Holmes LB

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:This study describes changes in the distribution of cigarette smoking and in physicians' advice to quit smoking among the U.S. population with and without diabetes from the mid-1970s to 1990. RESEARCH DESIGN AND METHODS:Data on self-reported smoking status, physicians' advice to quit smoking, history of diab...

journal_title：Diabetes care

authors： Malarcher AM,Ford ES,Nelson DE,Chrismon JH,Mowery P,Merritt RK,Herman WH

更新日期：1995-05-01 00:00:00

abstract：:OBJECTIVE--To determine and compare the abilities of various anthropometric measurements to predict the development of non-insulin-dependent diabetes mellitus (NIDDM) in Pima Indian men and women. RESEARCH DESIGN AND METHODS--A total of 290 male and 443 female Pima Indians were followed for up to 6 years for the devel...

journal_title：Diabetes care

authors： Warne DK,Charles MA,Hanson RL,Jacobsson LT,McCance DR,Knowler WC,Pettitt DJ

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:To examine the prevalence of cardiovascular disease in diabetic patients as a function of apolipoprotein (apo) E polymorphism. RESEARCH DESIGN AND METHODS:The apo E phenotypes and plasma lipid, lipoprotein, and apo levels were determined for 517 Italian diabetic patients. The prevalence of cardiovascular dis...

journal_title：Diabetes care

authors： Boemi M,Sirolla C,Amadio L,Fumelli P,Pometta D,James RW

更新日期：1995-04-01 00:00:00

abstract：:OBJECTIVE--To determine the prevalence of non-insulin-dependent diabetes mellitus (NIDDM), impaired glucose tolerance (IGT), and hypertension in a rural community of Bangladesh. RESEARCH DESIGN AND METHODS--A cluster sampling of 1,005 subjects > 15 years of age in the rural community of Dohar was investigated. Capilla...

journal_title：Diabetes care

authors： Abu Sayeed M,Banu A,Khan AR,Hussain MZ

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:Low plasma testosterone levels are associated with hyperinsulinemia and glucose intolerance in men. However, it is unclear whether these abnormalities are related to the concomitant alteration in regional adipose tissue (AT) accumulation associated with reduced androgen levels. RESEARCH DESIGN AND METHODS:We...

journal_title：Diabetes care

authors： Tchernof A,Després JP,Dupont A,Bélanger A,Nadeau A,Prud'homme D,Moorjani S,Lupien PJ,Labrie F

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:To describe the methods used to implement intensive and conventional therapies in the Diabetes Control and Complications Trial (DCCT) and the metabolic results that occurred with the different treatment regimens. RESEARCH DESIGN AND METHODS:The DCCT was a controlled clinical trial that demonstrated the benef...

journal_title：Diabetes care

authors：

更新日期：1995-03-01 00:00:00

abstract：OBJECTIVE:To describe the relative contributions of neurological and vascular abnormalities to the overall risk of diabetic foot ulceration. RESEARCH DESIGN AND METHODS:A case-control study of diabetic veterans from the Seattle Veterans Affairs Medical Center was conducted using data collected from 46 patients with di...

journal_title：Diabetes care

authors： McNeely MJ,Boyko EJ,Ahroni JH,Stensel VL,Reiber GE,Smith DG,Pecoraro RF

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVE:To understand why low-fat high-carbohydrate (CHO) diets lead to higher fasting and postprandial concentrations of triglyceride (TG)-rich lipoproteins in patients with non-insulin-dependent diabetes mellitus (NIDDM). RESEARCH DESIGN AND METHODS:Patients with NIDDM were placed randomly on diets containing eith...

journal_title：Diabetes care

authors： Chen YD,Coulston AM,Zhou MY,Hollenbeck CB,Reaven GM

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of topical human recombinant basic fibroblast growth factor (bFGF) on the healing of diabetic neurotrophic foot ulcers. RESEARCH DESIGN AND METHODS:Seventeen diabetic patients suffering from chronic neuropathic ulcer of the plantar surface of the foot entered a pilot, random...

journal_title：Diabetes care

authors： Richard JL,Parer-Richard C,Daures JP,Clouet S,Vannereau D,Bringer J,Rodier M,Jacob C,Comte-Bardonnet M

更新日期：1995-01-01 00:00:00

abstract：OBJECTIVE:Recent survey evidence suggests that sensory ataxia due to diabetic neuropathy may be a more frequent and serious problem than is commonly recognized. This view is further supported by research that confirms the major contribution of the somatosensory system to the control of posture. We therefore sought to d...

journal_title：Diabetes care

authors： Simoneau GG,Ulbrecht JS,Derr JA,Becker MB,Cavanagh PR

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To determine insulin-dependent diabetes mellitus (IDDM) incidence rates for the first time in Seoul, Korea, from 1985 to 1988. RESEARCH DESIGN AND METHODS:A mail survey was conducted among all hospitals, a total of 136, with > 80 beds in the Seoul area. Of these, (15.4%) hospitals reported patients with newl...

journal_title：Diabetes care

authors： Ko KW,Yang SW,Cho NH

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:To investigate whether intraperitoneal insulin (IPII) decreases the levels of circulating chylomicron remnants in patients with insulin-dependent diabetes mellitus (IDDM). RESEARCH DESIGN AND METHODS:Eight nonobese, normolipidemic IDDM patients were studied twice: before (while on subcutaneous insulin) and 6...

journal_title：Diabetes care

authors： Georgopoulos A,Saudek CD

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:A combined analysis of whether islet cell autoantibodies (ICAs) are cross-reactive with mouse pancreas, with glutamate decarboxylase (GAD) antibodies, and with 64K antibodies was performed in a large sample of recently diagnosed type I diabetic patients. The disappearance rates of these different autoantibodi...

journal_title：Diabetes care

authors： Chaillous L,Delamaire M,Martignat L,Maugendre D,Marre M,Mathieu E,Limal JM,Charbonnel B,Allannic H,Saï P

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To provide a description of the clinical characteristics that distinguish individuals who withhold insulin for weight control from those who do not. Some individuals with insulin-dependent diabetes mellitus (IDDM) control their weight by withholding insulin and purging excessive calories. This process places ...

journal_title：Diabetes care

authors： Biggs MM,Basco MR,Patterson G,Raskin P

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:To provide reliable data on the incidence of insulin-dependent diabetes mellitus (IDDM) in children (< 15 years of age) in Avellaneda, Argentina. RESEARCH DESIGN AND METHODS:A registry was established in Avellaneda, Argentina. The first registry was started in 1989, retrospective data collection was updated ...

journal_title：Diabetes care

authors： Sereday MS,Martí ML,Damiano MM,Moser ME

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:The Pima Indians of Arizona have the highest reported prevalences of obesity and non-insulin-dependent diabetes mellitus (NIDDM). In parallel with abrupt changes in lifestyle, these prevalences in Arizona Pimas have increased to epidemic proportions during the past decades. To assess the possible impact of th...

journal_title：Diabetes care

authors： Ravussin E,Valencia ME,Esparza J,Bennett PH,Schulz LO

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Hypoglycemic symptoms have been reported by more than half of pancreas transplantation (PTX) recipients. To better understand the mechanism for the hypoglycemia documented in some of these patients, we studied the glucose and pancreatic hormone response to Sustacal in patients with and without hypoglycemia fo...

journal_title：Diabetes care

authors： Tran MP,Larsen JL,Duckworth WC,Ruby EI,Miller SA,Frisbie K,Taylor RJ,Stratta RJ

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To determine the occurrence of elevated fetal hemoglobin (HbF) among the diabetic population and determine the clinical situation of importance. RESEARCH DESIGN AND METHODS:A cross-sectional study was conducted. HbA1c and HbF were measured with high-performance liquid chromatography in 1,104 consecutive diab...

journal_title：Diabetes care

authors： Koskinen LK,Lahtela JT,Koivula TA

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To determine the proportion of adults with diabetes in the U.S. who have received diabetes patient education and to assess factors that determine whether patients receive this education. RESEARCH DESIGN AND METHODS:A questionnaire on diabetes was administered to a representative sample of 2,405 diabetic indi...

journal_title：Diabetes care

authors： Coonrod BA,Betschart J,Harris MI

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of gastric emptying on postprandial insulin requirement in insulin-dependent diabetes mellitus (IDDM) patients with and without gastroparesis. RESEARCH DESIGN AND METHODS:Postprandial insulin requirement and gastric emptying were simultaneously evaluated in five IDDM patients with gast...

journal_title：Diabetes care

authors： Ishii M,Nakamura T,Kasai F,Onuma T,Baba T,Takebe K

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:To determine the frequency of hypoglycemia in patients with type I diabetes and impaired awareness of hypoglycemia by prospective assessment. RESEARCH DESIGN AND METHODS:A prospective study was undertaken for 12 months in 60 patients with type I diabetes: 29 had impaired awareness of hypoglycemia and 31 reta...

journal_title：Diabetes care

authors： Gold AE,MacLeod KM,Frier BM

更新日期：1994-07-01 00:00:00

abstract：OBJECTIVE:To determine the role of growth hormone (GH) in the development of diabetic retinopathy. RESEARCH DESIGN AND METHODS:Medical records of 1,423 patients who had undergone insulin tolerance tests (1976-1991) at the Mayo Clinic were examined, and diabetic subjects were identified as either GH-deficient (GH incre...

journal_title：Diabetes care

authors： Alzaid AA,Dinneen SF,Melton LJ 3rd,Rizza RA

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:To compare the prevalence of lumbar spondylolytic spondylolisthesis (LSS) in nondiabetic and diabetic subjects. RESEARCH DESIGN AND METHODS:A cross-sectional study of 1,147 randomly selected nondiabetic subjects and 892 non-insulin-dependent diabetes mellitus (NIDDM) patients, 45-64 years of age. LSS was dia...

journal_title：Diabetes care

authors： Virta L,Rönnemaa T,Laakso M

更新日期：1994-06-01 00:00:00

abstract：:The history of the National Diabetes Advisory Board is reviewed, particularly from the perspective of the role of the board in advancing diabetes care. In addition, its potential future activities in the arena of translating research advances, for example, the results of the Diabetes Control and Complications Trial (D...

journal_title：Diabetes care

authors： Genuth SM

更新日期：1994-06-01 00:00:00

abstract：OBJECTIVE:To evaluate glucose-based community screening for diabetes with regard to detection rate. RESEARCH DESIGN AND METHODS:A retrospective analysis of a community-screening questionnaire data base that included a screening for blood glucose. Referred subjects had fasting glucose levels > 6.4 mM (115 mg/dl) or pos...

journal_title：Diabetes care

authors： Newman WP,Nelson R,Scheer K

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To estimate the within-person variability (SDi) for the overnight urinary albumin excretion rate (AER) in diabetic patients with persistent microalbuminuria. RESEARCH DESIGN AND METHODS:Thirteen normotensive diabetic patients in stable medical control, with normal renal function and without any associated ca...

journal_title：Diabetes care

authors： Phillipou G,Phillips PJ

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:To determine the urinary endothelin-1-like immunoreactivity (ET-1-LI) in non-insulin-dependent diabetes mellitus (NIDDM) patients and to investigate whether urinary ET-1-LI excretion is elevated in patients with albuminuria. RESEARCH DESIGN AND METHODS:Urinary ET-1-LI substance was determined by radioimmunoa...

journal_title：Diabetes care

authors： Lee YJ,Shin SJ,Tsai JH

更新日期：1994-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the utility of a semipermeable polymeric membrane dressing for the treatment of chronic diabetic foot ulcers. RESEARCH DESIGN AND METHODS:Nineteen subjects with either insulin-dependent diabetes mellitus (IDDM) or non-insulin-dependent diabetes mellitus (NIDDM) and foot ulcers were randomly assig...

journal_title：Diabetes care

authors： Blackman JD,Senseng D,Quinn L,Mazzone T

更新日期：1994-04-01 00:00:00

abstract：:A higher prevalence of stroke is found in the patient with both diagnosed and undiagnosed diabetes and glucose intolerance. Because of local cerebral acidosis caused by ischemia and hyperglycemia, morbidity and mortality from a stroke are increased. Most studies show that individuals with admission serum glucose > 120...

journal_title：Diabetes care

authors： Bell DS

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:To understand the interrelationship of coronary artery disease (CAD) risk factors including hyperlipidemia, hypertension, and glucose intolerance to prevent and better manage this disease. RESEARCH DESIGN AND METHODS:We performed a 100-g oral glucose tolerance test in 2,113 subjects, and we evaluated their p...

journal_title：Diabetes care

authors： Yamada N,Yoshinaga H,Sakurai N,Shimano H,Gotoda T,Ohashi Y,Yazaki Y,Kosaka K

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:To determine the rheological properties of polymorphonuclear leukocytes (PMN) from non-insulin-dependent diabetes mellitus (NIDDM) patients. RESEARCH DESIGN AND METHODS:The deformability of PMN from 33 NIDDM subjects, 13 with impaired glucose tolerance (IGT), and 22 with normal glucose tolerance (NGT) was st...

journal_title：Diabetes care

authors： Pécsvarády Z,Fisher TC,Darwin CH,Fabók A,Maqueda TS,Saad MF,Meiselman HJ

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:To examine the effect of prior meal ingestion on the glucose, insulin, and C-peptide response to a 50-g glucose challenge test in the third trimester of pregnancy. RESEARCH DESIGN AND METHODS:Ten pregnant women with gestational diabetes mellitus and 12 nondiabetic pregnant control subjects matched for age an...

journal_title：Diabetes care

authors： Lewis GF,McNally C,Blackman JD,Polonsky KS,Barron WM

更新日期：1993-12-01 00:00:00

abstract：:This paper provides some historical aspects on the research and development of Humulin (rDNA origin), the first human health-care product derived from rDNA technology more than a decade ago. Also referred to as biosynthetic human insulin, Humulin is currently produced via the human proinsulin route, using an Escherich...

journal_title：Diabetes care

authors： Chance RE,Frank BH

更新日期：1993-12-01 00:00:00

abstract：:A major problem in replacing insulin in type I diabetes mellitus is that currently no depot preparation exists that is capable of mimicking the background insulin secretion of the healthy pancreas. Because all of the currently available intermediate- or long-acting insulin preparations have a peaked-action profile, ex...

journal_title：Diabetes care

authors： Bolli GB,Perriello G,Fanelli CG,De Feo P

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:To compare the influence on blood pressure, glucose, and lipid levels of a diet rich in monounsaturated fatty acids with an isocaloric, high-carbohydrate diet in 15 NIDDM subjects. RESEARCH DESIGN AND METHODS:A crossover design with diet interventions and wash-out periods of 3 wk was applied. The patients we...

journal_title：Diabetes care

authors： Rasmussen OW,Thomsen C,Hansen KW,Vesterlund M,Winther E,Hermansen K

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:To relate deterioration in kidney function to some potential cardiovascular risk factors in type II diabetic patients. RESEARCH DESIGN AND METHODS:Twenty-four normoalbuminuric and 13 microalbuminuric patients completed a 3.4-yr prospective observational study. Glomerular filtration rate, urinary albumin excr...

journal_title：Diabetes care

authors： Nielsen S,Schmitz A,Rehling M,Mogensen CE

更新日期：1993-11-01 00:00:00